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As one review stated, Nicotine is the addictive chemical in tobacco smoke, but its involvement in smoking-related harm (outside pregnancy) is very small, if any, compared to cigarette smoking. Another systematic review pointed out that nicotine can have a variety of potential health effects, from raising ones cardiovascular risk to causing birth defects in pregnant women

Pulmonary Angiogram The most accurate test, involving the insertion of a catheter and contrast dye to visualise blood flow in the lung arteries, though it carries some risks

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ISBN 978-0-553-51061-4